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Review
. 2014 Oct;19(5):249-54.
doi: 10.1097/MBP.0000000000000060.

Clock genes in hypertension: novel insights from rodent models

Jacob Richards  1 , Alexander N Diaz, Michelle L Gumz
Affiliations
Review

Clock genes in hypertension: novel insights from rodent models

Jacob Richards et al. Blood Press Monit. 2014 Oct.

Abstract

The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including hypertension. Recent work has implicated the circadian clock genes in the regulation of processes in the heart, kidney, vasculature, and the metabolic organs, which are all critical in the regulation of the blood pressure. The goal of this review is to provide an introduction and general overview into the role of circadian clock genes in the regulation of blood pressure with a focus on their deregulation in the etiology of hypertension. This review will focus on the core circadian clock genes CLOCK, BMAL1, Per, and Cry.

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Figures

Figure 1
Figure 1. Transcription Translation Oscillating (TTO) loop
Clock and Bmal1 heterodimerize to activate transcription of circadian target genes including the genes of Per (homologs: 1-3) and Cry(homologs:1-2). Per and Cry interact and inhibit Bmal1 and Clock.
Figure 2
Figure 2. Role of Circadian Clock Genes in Blood pressure
The role of each clock gene is organized by organ and its role in regulation of blood pressure. If a protein is not listed, it does not imply that it is not involved, but that it has not yet been tested. Numbers are indicative of respective references.
See this image and copyright information in PMC

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