Amitriptyline
Amitriptyline, igurishwa ku izina rya Elavil n'indi, ni umuti ukoreshwa cyane cyane mu kuvura indwara nyinshi zo mu mutwe.[1] Ibi birimo indwara ikomeye yo kwiheba no guhangayika, hamwe n'indwara idakunze kugaragara yo kudakora neza (ADHD) na indwara yo gucika intege.[1][2] Izindi ngamba zirimo kwirinda indwara ya migraine, kuvura ububabare bw'imitsi nka fibromyalgia na neuralgia yo mu gihe cy'imitsi, ndetse no kudasinzira cyane.[3] Iri mu bwoko bwa tricyclic antidepressant (TCA) kandi imikorere yayo nyayo ntabwo isobanutse neza.[1] Amitriptyline ifatwa mu kanwa.[1]
Ingaruka mbi zikunze kugaragara zirimo kutabona neza, umunwa wumye, umuvuduko muke w'amaraso uhagaze, gusinzira no kutagira impatwe . Ingaruka mbi zishobora kuba zirimo gucika intege, ibyago byinshi byo kwiyahura ku bantu bari munsi y'imyaka 25, kubura inkari, glaucoma, n'ibibazo byinshi by'umutima.[1] Ntibikwiye gufatwa hamwe n'imiti igabanya ubukana bwa MAO cyangwa umuti wa cisapride.[1] Amitriptyline ishobora guteza ibibazo iyo ifashwe mu gihe cyo gutwita.[1] Gukoresha mu gihe cyo konsa bisa nkaho ari byiza ku rugero runaka.
Amitriptyline yavumbuwe mu 1960 [4] yemezwa n'Ikigo gishinzwe ibiribwa n'imiti muri Amerika (FDA) mu 1961.[5] Iri ku rutonde rw'imiti y'ingenzi y'Umuryango w'Abibumbye wita ku Buzima.[6] Iraboneka nk'umuti usanzwe . Igiciro cy'igurishwa ry'ibicuruzwa mu bihugu biri mu nzira y'amajyambere as of 2014[update] yari hagati ya 0.01 na 0.04 by'amadolari ya Amerika kuri dose. Muri Leta Zunze Ubumwe za Amerika, igura hafi amadolari y'Amerika 0.20 kuri buri dose.[1] Mu 2017, wari umuti wa 87 ukunze kwandikirwa muri Leta Zunze Ubumwe za Amerika, aho wanditswe n’abaganga barenga miliyoni icyenda.
Iriburiro
[Hindura | hindura inkomoko]- 1 2 3 4 5 6 7 8 "Amitriptyline Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 24 September 2014. Retrieved 25 September 2014. Archived 24 Nzeri 2014 at the Wayback Machine
- ↑ Leucht C, Huhn M, Leucht S (December 2012). "Amitriptyline versus placebo for major depressive disorder". The Cochrane Database of Systematic Reviews. 12: CD009138. doi:10.1002/14651858.CD009138.pub2. PMID 23235671.
- ↑ Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ (July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane Database of Systematic Reviews. 7 (7): CD008242. doi:10.1002/14651858.CD008242.pub3. PMC 6447238. PMID 26146793.
- ↑ Sneader, Walter (2005). Drug Discovery a History. Chichester: John Wiley & Sons. p. 414. ISBN 9780470015520. Archived from the original on 8 September 2017.
- ↑ Fangmann P, Assion HJ, Juckel G, González CA, López-Muñoz F (February 2008). "Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part II: tricyclics and tetracyclics". Journal of Clinical Psychopharmacology. 28 (1): 1–4. doi:10.1097/jcp.0b013e3181627b60. PMID 18204333. S2CID 31018835.
- ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
