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Ketoconazole

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Ketoconazole
Ketoconazole

Ketoconazole, igurishwa ku izina rya Nizoral n'indi, ni umuti uvura indwara ziterwa n'imiti irwanya udukoko ukoreshwa mu kuvura indwara zitandukanye z'imiti.[1] Iyo ikoreshejwe ku ruhu, ikoreshwa mu kuvura indwara z'uruhu ziterwa n'ibihumyo nka tinea, candidiasis y'uruhu, pityriasis versicolor, dandruff, na seborrheic dermatitis.[2] Iyo uyinyoye ntabwo ari amahitamo meza cyane kandi ni byiza kuyikoresha gusa ku ndwara zikomeye mu gihe izindi miti zidashobora gukoreshwa.[1] Izindi ngamba zirimo kuvura imikurire y'umusatsi ikabije ndetse n'indwara ya Cushing's syndrome.[1]

Ingaruka mbi zikunze kugaragara iyo zikoreshejwe ku ruhu zirimo gutukura, kuribwa no kuruma.[3] Ingaruka mbi zikunze kugaragara iyo umuntu anyoye zirimo isesemi, kuribwa umutwe, n'ibibazo by'umwijima.[1] Ibibazo by'umwijima bishobora gutera urupfu cyangwa gukenera guterwa umwijima.[1][4] Izindi ngaruka mbi zikomeye iyo umuntu anyoye zirimo gukomeretsa QT, kudakora neza kw'uturemangingo tw'amaraso, no kunanirwa k'umubiri.[1][4] Ni imidazole kandi ikora mu kugira ingaruka ku ikorwa rya ergosterol ikenewe ku ruhu rw'uturemangingo tw'ibihumyo bityo igatuma gukura kugabanuka.[1]

Ketoconazole yahawe uburenganzira bwo gukoresha imiti mu 1977, itangira gukoreshwa mu buvuzi mu 1981.[5] Iraboneka nk'umuti usanzwe kandi imiti ikoreshwa ku ruhu igurishwa ku giciro cya muganga mu Bwongereza.[2] Umuyoboro wa garama 30 mu Bwongereza utwara NHS munsi y'amapawundi 5 mu 2019.[2] Muri Leta Zunze Ubumwe za Amerika, aho amavuta yo mu bwoko bwa "topical cream" aboneka gusa ku muganga, ikiguzi cy'aya mafaranga ni hafi US$6.30.[6] Mu 2017, wari umuti wa 219 ukunze kwandikirwa muri Leta Zunze Ubumwe za Amerika, aho wanditswe n'abaganga barenga miliyoni ebyiri.[7][8] Iyi ngingo ifatwa mu kanwa yakuweho mu Muryango w’Ubumwe bw’u Burayi no muri Ositaraliya mu 2013 [9][10] no mu Bushinwa mu 2015.[11] Byongeye kandi, ikoreshwa ryayo ryaragabanijwe muri Leta Zunze Ubumwe za Amerika na Kanada mu 2013.[10]

Iriburiro

[Hindura | hindura inkomoko]
  1. 1 2 3 4 5 6 7 "Ketoconazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 December 2010. Retrieved 23 March 2019.
  2. 1 2 3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1198. ISBN 9780857113382.
  3. ↑ Gupta, Aditya K.; Mays, Rachel R.; Folley, Kelly A. (2019). "42. Topical antifungal agents". In Wolverton, Stephen E.; Wu, Jashin J. (eds.). Comprehensive Dermatologic Drug Therapy (in Icyongereza) (4th ed.). Elsevier. p. 484. ISBN 978-0-323-61211-1. Archived from the original on 9 October 2021. Retrieved 7 October 2021.
  4. 1 2 "FDA limits usage of Nizoral (ketoconazole) oral tablets due to potentially fatal liver injury and risk of drug interactions and adrenal gland problems". FDA Drug Safety Communication. U.S. Food and Drug Administration. July 26, 2013. Archived from the original on December 2, 2013. Retrieved November 23, 2013.
  5. ↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 503. ISBN 9783527607495. Archived from the original on 2 August 2020. Retrieved 2 March 2019.
  6. ↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  7. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  8. ↑ "Ketoconazole - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
  9. ↑ "Oral ketoconazole (Nizoral) 200 mg tablets". Therapeutic Goods Administration (TGA). 10 October 2013. Archived from the original on 2 July 2015. Retrieved 23 March 2019.
  10. 1 2 Gupta AK, Lyons DC (2015). "The Rise and Fall of Oral Ketoconazole". Journal of Cutaneous Medicine and Surgery. 19 (4): 352–7. doi:10.1177/1203475415574970. PMID 25775613.
  11. ↑ "国家食品药品监督管理总局关于停止生产销售使用酮康唑口服制剂的公告（2015年第85号）" (in Chinese). China Food and Drug Administration. 2015-06-25. Archived from the original on 2015-07-02. Retrieved 2015-07-02.
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