Natural and Induced T Regulatory Cells in Cancer

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,

²

,

³

et al. 2019

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…To establish a direct link between the MDSC and Treg in CHI, we co‐cultured sorted MDSC with autologous MDSC‐depleted PBMC from study subjects and demonstrated significant increase in iTreg and Tr1 but not Th3‐cells, in IT and EP‐/EN‐CHB patients while similar phenomenon was not witnessed in case of IC or HC. The conversion of peripheral naïve CD4 + CD25 − T‐cells to iTreg had been described in previous studies and we also noted a decline in CD4 + CD25 ‐ T cells with a parallel increase in CD4 + CD25 + FOXP3 + iTreg during MDSC‐PBMC co‐culture, implying that this FOXP3 + population would have been derived from the naïve T‐cells (Figure S3). However, we cannot rule out the possibility that selective expansion of a pre‐existing population of FOXP3 + Treg by MDSC could have also contributed to the increase in the Treg pool, as reported in lymphoma‐bearing mice .…”

Section: Discussion

supporting

confidence: 85%

Myeloid‐derived suppressor cells induce regulatory T cells in chronically HBV infected patients with high levels of hepatitis B surface antigen and persist after antiviral therapy

¹

,

²

,

³

et al. 2019

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…To establish a direct link between the MDSC and Treg in CHI, we co‐cultured sorted MDSC with autologous MDSC‐depleted PBMC from study subjects and demonstrated significant increase in iTreg and Tr1 but not Th3‐cells, in IT and EP‐/EN‐CHB patients while similar phenomenon was not witnessed in case of IC or HC. The conversion of peripheral naïve CD4 + CD25 − T‐cells to iTreg had been described in previous studies and we also noted a decline in CD4 + CD25 ‐ T cells with a parallel increase in CD4 + CD25 + FOXP3 + iTreg during MDSC‐PBMC co‐culture, implying that this FOXP3 + population would have been derived from the naïve T‐cells (Figure S3). However, we cannot rule out the possibility that selective expansion of a pre‐existing population of FOXP3 + Treg by MDSC could have also contributed to the increase in the Treg pool, as reported in lymphoma‐bearing mice .…”

Section: Discussion

supporting

confidence: 85%

Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy

Milanović

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,

Pavlović

²

,

Bekić

³

et al. 2026

Int. J. Biol. Sci.

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This is in line with our finding that αKG-moMDSCs induction of Tr1 cells can be blocked by either anti-ILT4 Ab, or by anti-IL-10. TGF-β-producing induced Tr2 cells are also dependent on IL-10 98 , but this is the first report showing that ILT-4 is also involved in their induction. Although IL-10 is known inducer of ILT-4 97 , we showed that the ILT-4 upregulation in αKG-moMDSCs is not dependent on autophagy and IL-10, suggesting the involvement of alternative mechanisms regulating its expression.…”

Section: Discussion

mentioning

confidence: 79%

Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis

Cari

¹

,

Nocentini

²

,

Migliorati

³

et al. 2017

OncoImmunology

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…2 and Table S3) and had an overall score of 16 as far as concerns correlation with the suppressive microenvironment of tumors (ranked fourteenth among the Treg markers, Table 5), confirming that Tregs different from tTregs play a more relevant role in tumors than that played by tTregs, as demonstrated by others. 3 A limitation of this study is that the level of mRNA expression of the markers did not always correlate with the level of protein expression. However, it is known that GITR, TNFR2 and CTLA-4 are overexpressed in tumor-infiltrating Tregs.…”

Section: Limitations and Strengths Of The Study

mentioning

confidence: 80%

Myeloid‐derived suppressor cells induce regulatory T cells in chronically HBV infected patients with high levels of hepatitis B surface antigen and persist after antiviral therapy

¹

,

²

,

³

et al. 2019

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…To establish a direct link between the MDSC and Treg in CHI, we co‐cultured sorted MDSC with autologous MDSC‐depleted PBMC from study subjects and demonstrated significant increase in iTreg and Tr1 but not Th3‐cells, in IT and EP‐/EN‐CHB patients while similar phenomenon was not witnessed in case of IC or HC. The conversion of peripheral naïve CD4 + CD25 − T‐cells to iTreg had been described in previous studies and we also noted a decline in CD4 + CD25 ‐ T cells with a parallel increase in CD4 + CD25 + FOXP3 + iTreg during MDSC‐PBMC co‐culture, implying that this FOXP3 + population would have been derived from the naïve T‐cells (Figure S3). However, we cannot rule out the possibility that selective expansion of a pre‐existing population of FOXP3 + Treg by MDSC could have also contributed to the increase in the Treg pool, as reported in lymphoma‐bearing mice .…”

Section: Discussion

supporting

confidence: 85%

Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy

Milanović

¹

,

Pavlović

²

,

Bekić

³

et al. 2026

Int. J. Biol. Sci.

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This is in line with our finding that αKG-moMDSCs induction of Tr1 cells can be blocked by either anti-ILT4 Ab, or by anti-IL-10. TGF-β-producing induced Tr2 cells are also dependent on IL-10 98 , but this is the first report showing that ILT-4 is also involved in their induction. Although IL-10 is known inducer of ILT-4 97 , we showed that the ILT-4 upregulation in αKG-moMDSCs is not dependent on autophagy and IL-10, suggesting the involvement of alternative mechanisms regulating its expression.…”

Section: Discussion

mentioning

confidence: 79%

Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis

Cari

¹

,

Nocentini

²

,

Migliorati

³

et al. 2017

OncoImmunology

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…2 and Table S3) and had an overall score of 16 as far as concerns correlation with the suppressive microenvironment of tumors (ranked fourteenth among the Treg markers, Table 5), confirming that Tregs different from tTregs play a more relevant role in tumors than that played by tTregs, as demonstrated by others. 3 A limitation of this study is that the level of mRNA expression of the markers did not always correlate with the level of protein expression. However, it is known that GITR, TNFR2 and CTLA-4 are overexpressed in tumor-infiltrating Tregs.…”

Section: Limitations and Strengths Of The Study

mentioning

confidence: 80%

Myeloid‐derived suppressor cells induce regulatory T cells in chronically HBV infected patients with high levels of hepatitis B surface antigen and persist after antiviral therapy

¹

,

²

,

³

et al. 2019

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…To establish a direct link between the MDSC and Treg in CHI, we co‐cultured sorted MDSC with autologous MDSC‐depleted PBMC from study subjects and demonstrated significant increase in iTreg and Tr1 but not Th3‐cells, in IT and EP‐/EN‐CHB patients while similar phenomenon was not witnessed in case of IC or HC. The conversion of peripheral naïve CD4 + CD25 − T‐cells to iTreg had been described in previous studies and we also noted a decline in CD4 + CD25 ‐ T cells with a parallel increase in CD4 + CD25 + FOXP3 + iTreg during MDSC‐PBMC co‐culture, implying that this FOXP3 + population would have been derived from the naïve T‐cells (Figure S3). However, we cannot rule out the possibility that selective expansion of a pre‐existing population of FOXP3 + Treg by MDSC could have also contributed to the increase in the Treg pool, as reported in lymphoma‐bearing mice .…”

Section: Discussion

supporting

confidence: 85%

Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy

Milanović

¹

,

Pavlović

²

,

Bekić

³

et al. 2026

Int. J. Biol. Sci.

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…This is in line with our finding that αKG-moMDSCs induction of Tr1 cells can be blocked by either anti-ILT4 Ab, or by anti-IL-10. TGF-β-producing induced Tr2 cells are also dependent on IL-10 98 , but this is the first report showing that ILT-4 is also involved in their induction. Although IL-10 is known inducer of ILT-4 97 , we showed that the ILT-4 upregulation in αKG-moMDSCs is not dependent on autophagy and IL-10, suggesting the involvement of alternative mechanisms regulating its expression.…”

Section: Discussion

mentioning

confidence: 79%

Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis

Cari

¹

,

Nocentini

²

,

Migliorati

³

et al. 2017

OncoImmunology

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…2 and Table S3) and had an overall score of 16 as far as concerns correlation with the suppressive microenvironment of tumors (ranked fourteenth among the Treg markers, Table 5), confirming that Tregs different from tTregs play a more relevant role in tumors than that played by tTregs, as demonstrated by others. 3 A limitation of this study is that the level of mRNA expression of the markers did not always correlate with the level of protein expression. However, it is known that GITR, TNFR2 and CTLA-4 are overexpressed in tumor-infiltrating Tregs.…”

Section: Limitations and Strengths Of The Study

mentioning

confidence: 80%