Dimerkaprol

Dimerkaprol
Nazivi
	Drugi nazivi Bal In Oil Injection, Dimercaprol
Identifikacija
CAS broj	59-52-9 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:554382 ;
ChemSpider	2971 ;
DrugBank	DB06782;
ECHA InfoCard	100.000.394
KEGG	C02924 ;
PubChem C ID	3080;
	SMILES OCC(S)CS; ; ; ; ; ;
Svojstva
Hemijska formula	C3H8OS2
Molarna masa	124,225
Tačka topljenja	<
Tačka ključanja	140
Farmakologija
Način primene	Intramaskularno
	Farmakokinetika:
Izlučivanje	Urinom
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Dimerkaprol je organsko jedinjenje, koje sadrži 3 atoma ugljenika i ima molekulsku masu od 124,225 Da.^[4]^[5]^[6]^[7]^[8]^[9]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	3
Broj rotacionih veza	2
Particioni koeficijent^[10] (ALogP)	0,5
Rastvorljivost^[11] (logS, log(mol/L))	1,5
Polarna površina^[12] (PSA, Å²)	97,8

Reference

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Walshe JM: The conquest of Wilson's disease. Brain. ;132(Pt 8):2289-95. Epub 2009 Jul 13. Walshe, J. M. (2009 Aug). „The conquest of Wilson's disease”. Brain : A Journal of Neurology. 132 (Pt 8): 2289—2295. PMID 19596747. doi:10.1093/brain/awp149. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Boscolo M, Antonucci S, Volpe AR, Carmignani M, Di Gioacchino M: Acute mercury intoxication and use of chelating agents. J Biol Regul Homeost Agents. ;Boscolo, M.; Antonucci, S.; Volpe, A. R.; Carmignani, M.; Di Gioacchino, M. (2009 Oct-Dec). „Acute mercury intoxication and use of chelating agents”. Journal of Biological Regulators and Homeostatic Agents. 23 (4): 217—23. PMID 20003760. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Flora SJ, Pachauri V: Chelation in metal intoxication. . Flora, Swaran J.S.; Pachauri, Vidhu (јул 2010). „Chelation in Metal Intoxication”. Int J Environ Res Public Health. 7 (7): 2745—88. PMID 20717537. doi:10.3390/ijerph7072745 . . Epub 2010 Jun 28.
^ Andersen O: Chemical and biological considerations in the treatment of metal intoxications by chelating agents. Mini Rev Med Chem. Andersen, O. (јануар 2004). „Chemical and biological considerations in the treatment of metal intoxications by chelating agents”. Mini Reviews in Medicinal Chemistry. 4 (1): 11—21. PMID 14754439. doi:10.2174/1389557043487583.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.
Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th изд.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.

Spoljašnje veze

Dimercaprol Архивирано на веб-сајту Wayback Machine (22. фебруар 2014)

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Walshe JM: The conquest of Wilson's disease. Brain. ;132(Pt 8):2289-95. Epub 2009 Jul 13. Walshe, J. M. (2009 Aug). „The conquest of Wilson's disease”. Brain : A Journal of Neurology. 132 (Pt 8): 2289—2295. PMID 19596747. doi:10.1093/brain/awp149. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Boscolo M, Antonucci S, Volpe AR, Carmignani M, Di Gioacchino M: Acute mercury intoxication and use of chelating agents. J Biol Regul Homeost Agents. ;Boscolo, M.; Antonucci, S.; Volpe, A. R.; Carmignani, M.; Di Gioacchino, M. (2009 Oct-Dec). „Acute mercury intoxication and use of chelating agents”. Journal of Biological Regulators and Homeostatic Agents. 23 (4): 217—23. PMID 20003760. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[6] Flora SJ, Pachauri V: Chelation in metal intoxication. . Flora, Swaran J.S.; Pachauri, Vidhu (јул 2010). „Chelation in Metal Intoxication”. Int J Environ Res Public Health. 7 (7): 2745—88. PMID 20717537. doi:10.3390/ijerph7072745 . . Epub 2010 Jun 28.

[7] Andersen O: Chemical and biological considerations in the treatment of metal intoxications by chelating agents. Mini Rev Med Chem. Andersen, O. (јануар 2004). „Chemical and biological considerations in the treatment of metal intoxications by chelating agents”. Mini Reviews in Medicinal Chemistry. 4 (1): 11—21. PMID 14754439. doi:10.2174/1389557043487583.

[8] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[9] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[10] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[11] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[12] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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