Jens Luebeck

@Jens_Luebeck

Cancer genomics · extrachromosomal DNA #ecDNA · computational methods & bioinformatics · Associate Project Scientist at @UCSanDiego @ucsd_cse 💻🧬

jluebeck.github.io

Joined December 2015

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521 Followers

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Jens Luebeck
@Jens_Luebeck
Oct 20
Our paper on AmpliconSuite and AmpliconRepository.org, tools for studying gene amplifications like extrachromosomal DNA (#ecDNA) in cancer genomes is now published. Grateful to the many colleagues who built these resources with us. nature.com/articles/s4159…
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Jens Luebeck
@Jens_Luebeck
Oct 20
Thank you @CancerGrand for featuring our new work on AmpliconSuite and AmpliconRepository, and the story behind it. The paper is available here: nature.com/articles/s4159…
Cancer Grand Challenges
@CancerGrand
Oct 20
Great scientific tools aren't built in isolation 👥 For @Jens_Luebeck, Paul Mischel, @VineetBafna3 and the rest of team eDyNAmiC, developing new ways to detect and analyse extrachromosomal DNA (ecDNA) in cancer means bringing together expertise from across disciplines, and key
Jens Luebeck
@Jens_Luebeck
Oct 12
New preprint from the Bafna lab - "Inferring ecDNA emergence time and selection strength from allele frequency spectra." Led by PhD student Bhargavi Dameracharla biorxiv.org/content/10.648…
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Jens Luebeck
@Jens_Luebeck
Dec 18, 2024
Inducible ecDNA that give robust, strong amplifications that are persistent over time! This can create amazing new model systems to study ecDNA. Congratulations to Andrea and team for pioneering this work.
Andrea Ventura
@aventura71
Dec 18, 2024
1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…
Jens Luebeck
@Jens_Luebeck
Nov 6, 2024
One of the most frequent questions I hear about ecDNA is "why does it matter how oncogenes are amplified?" These three amazing papers out today answer that and many more questions. Particularly, check out how the unique biology of ecDNA exposes a therapeutic vulnerability! 👇3⃣
Cancer Grand Challenges
@CancerGrand
Nov 6, 2024
Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in @Nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00
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Jens Luebeck

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