6-MAPB explained

6-MAPB (1-(benzofuran-6-yl)-N-methylpropan-2-amine) is an entactogen of the benzofuran family which is structurally related to 6-APB and MDMA.[1] [2] [3] [4] [5] It is known to be a serotonin releasing agent and, unlike MDMA, a potent serotonin 5-HT1B receptor agonist.[6] The drug is not known to have been widely sold as a "designer drug" but has been detected in analytical samples taken from individuals hospitalised after using drug combinations that included other benzofuran derivatives. 6-MAPB was first encountered as a novel designer drug in 2013 and described in the scientific literature in 2014.[7] [8] It was banned in the United Kingdom in June 2013, along with 9 other related compounds which were thought to produce similar effects.[9]

Interactions

See also: MDMA/citalopram.

See also

External links

Notes and References

  1. Oeri HE . Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy . J Psychopharmacol . 35 . 5 . 512–536 . May 2021 . 32909493 . 8155739 . 10.1177/0269881120920420 .
  2. Welter J, Brandt SD, Kavanagh P, Meyer MR, Maurer HH . Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MS(n) techniques . Analytical and Bioanalytical Chemistry . 407 . 12 . 3457–3470 . May 2015 . 25711990 . 10.1007/s00216-015-8552-2 . 5475974 .
  3. Welter-Luedeke J, Maurer HH . New Psychoactive Substances: Chemistry, Pharmacology, Metabolism, and Detectability of Amphetamine Derivatives With Modified Ring Systems . Therapeutic Drug Monitoring . 38 . 1 . 4–11 . February 2016 . 26327309 . 10.1097/FTD.0000000000000240 . 20737913 .
  4. Shimshoni JA, Winkler I, Golan E, Nutt D . Neurochemical binding profiles of novel indole and benzofuran MDMA analogues . Naunyn-Schmiedeberg's Archives of Pharmacology . 390 . 1 . 15–24 . January 2017 . 27650729 . 10.1007/s00210-016-1297-4 . 10044/1/43622 . 253741131 . free .
  5. Brandt SD, Walters HM, Partilla JS, Blough BE, Kavanagh PV, Baumann MH . The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats . Psychopharmacology . 237 . 12 . 3703–3714 . December 2020 . 32875347 . 10.1007/s00213-020-05648-z . 7686291 .
  6. US . 20230150963 . . Advantageous benzofuran compositions for mental disorders or enhancement . 2023 May 18 . 2022 December 8 . 2022 December 8 . .
  7. King LA . New phenethylamines in Europe . Drug Test Anal . 6 . 7-8 . 808–818 . 2014 . 24574327 . 10.1002/dta.1570 .
  8. https://isomerdesign.com/bitnest/external/EMCDDA/New-Drugs-In-Europe-2013
  9. Web site: Temporary class drug order report on 5-6APB and NBOMe compounds . 2013-07-10 . 4 Jun 2013 . UK Home Office.

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