EMDT explained

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT₆ receptor agonist, with a K_i of 16nM, and was one of the first selective agonists developed for this receptor.^{[1] [2]} Its affinities for many other targets have also been reported. EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT₆ antagonist SB-399,885.^[3] Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.^[4]

See also

• Substituted tryptamine
• 2-Methyltryptamine
• BGC20-761
• EMD-386,088
• ST-1936

Notes and References

1. Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK . 6 . 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors . Journal of Medicinal Chemistry . 43 . 5 . 1011–1018 . March 2000 . 10715164 . 10.1021/jm990550b . Bryan Roth .
2. Ray TS . Psychedelics and the human receptorome . PLOS ONE . 5 . 2 . e9019 . February 2010 . 20126400 . 2814854 . 10.1371/journal.pone.0009019 . free . 2010PLoSO...5.9019R .
3. Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E . The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation . Behavioural Brain Research . 195 . 1 . 112–119 . December 2008 . 18191236 . 10.1016/j.bbr.2007.11.023 . 144901859 .
4. Svenningsson P, Tzavara ET, Qi H, Carruthers R, Witkin JM, Nomikos GG, Greengard P . Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation . The Journal of Neuroscience . 27 . 15 . 4201–4209 . April 2007 . 17428998 . 6672541 . 10.1523/JNEUROSCI.3110-06.2007 . free .