Fluorodopa (18F) Explained

Drug Name:	Fluorodopa
Image Class:	skin-invert-image
Tradename:	Fluorodopa F18
Dailymedid:	Fluorodopa
Routes Of Administration:	Intravenous
Atc Prefix:	V09
Atc Suffix:	IX05
Legal Us:	Rx-only
Cas Number:	92812-82-3
Pubchem:	56494
Drugbank:	DB13848
Chemspiderid:	50970
Unii:	2C598205QX
Kegg:	D04220
Chebi:	49166
Chembl:	3400972
Synonyms:	6-fluoro-L-DOPA, FDOPA
Iupac Name:	(2S)-2-amino-3-(2-(18F)fluoranyl-4,5-dihydroxyphenyl)propanoic acid
C:	9
H:	10
F:	1
N:	1
O:	4
Smiles:	C1=C(C(=CC(=C1O)O)F)CC(C(=O)O)N
Stdinchi:	1S/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1/i10-1
Stdinchikey:	PAXWQORCRCBOCU-RPDRGXCHSA-N

Fluorodopa (¹⁸F), also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET).^[1]

The most common side effects are injection site pain.

Medical uses

Fluorodopa (¹⁸F) is indicated for use in positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adults with suspected Parkinsonian syndromes.^[2]

History

In October 2019, Fluorodopa (¹⁸F) was approved in the United States for the visual detection of certain nerve cells in adults with suspected Parkinsonian syndromes.^[3] ^[4]

The US Food and Drug Administration approved Fluorodopa F 18 based on evidence from one clinical trial of 56 participants with suspected Parkinsonian syndromes. The trial was conducted at one clinical site in the United States.

Notes and References

Deng WP, Wong KA, Kirk KL . Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA . Tetrahedron: Asymmetry . 13 . 11 . 1135–1140 . June 2002 . 10.1016/S0957-4166(02)00321-X.
Web site: Fluorodopa F18 injection . DailyMed . 12 October 2019 . 26 April 2020.
Web site: Drug Trials Snapshots: Fluorodopa F 18 . U.S. Food and Drug Administration (FDA) . 27 November 2019 . https://web.archive.org/web/20191127041549/https://www.fda.gov/drugs/drug-trials-snapshots-fluorodopa-f-18 . 27 November 2019 . dead . 27 November 2019.
Web site: Drug Approval Package: Fluorodopa F18 . U.S. Food and Drug Administration (FDA) . 20 November 2019 . https://web.archive.org/web/20191127043009/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/200655Orig1s000TOC.cfm . 27 November 2019 . dead . 26 November 2019.