IFIT2 explained

Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene.^{[1] [2] [3]} Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein.^[4] The IFIT2 gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one of the many type 1 interferon-stimulated genes.^{[4] [5] [6]}

Clinical significance

IFIT2 may play a role in preventing tumor progression.^[7] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[9]

Further reading

• Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G . The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24 . Genomics . 13 . 2 . 458–60 . 1992 . 1377167 . 10.1016/0888-7543(92)90272-T .
• Wathelet MG, Clauss IM, Content J, Huez GA . Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses . Eur. J. Biochem. . 174 . 2 . 323–9 . 1988 . 2454816 . 10.1111/j.1432-1033.1988.tb14101.x .
• Ulker N, Zhang X, Samuel CE . Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component . J. Biol. Chem. . 262 . 35 . 16798–803 . 1988 . 10.1016/S0021-9258(18)45454-3 . 3119591 . free .
• Levy D, Larner A, Chaudhuri A, Babiss LE, Darnell JE . Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region . Proc. Natl. Acad. Sci. U.S.A. . 83 . 23 . 8929–33 . 1987 . 3466167 . 387047 . 10.1073/pnas.83.23.8929 . free .
• Zhu H, Cong JP, Shenk T . Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs . Proc. Natl. Acad. Sci. U.S.A. . 94 . 25 . 13985–90 . 1998 . 9391139 . 28419 . 10.1073/pnas.94.25.13985 . free .
• Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, Filiukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED . [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus] . Bioorg. Khim. . 29 . 2 . 175–80 . 2003 . 12708317 . 10.1023/a:1023260415910. 34300356 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Terenzi F, Hui DJ, Merrick WC, Sen GC . Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56 . J. Biol. Chem. . 281 . 45 . 34064–71 . 2006 . 16973618 . 10.1074/jbc.M605771200 . free .
• Saha S, Sugumar P, Bhandari P, Rangarajan PN . Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein . J. Gen. Virol. . 87 . Pt 11 . 3285–9 . 2006 . 17030862 . 10.1099/vir.0.82107-0 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C . Cloning and chromosomal location of human genes inducible by type I interferon . Somat Cell Mol Genet . 14 . 5 . 415–26 . Nov 1988 . 3175763 . 10.1007/BF01534709. 42406993 .
2. Wathelet MG, Clauss IM, Content J, Huez GA . The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family . FEBS Lett . 231 . 1 . 164–71 . Jun 1988 . 3360121 . 10.1016/0014-5793(88)80724-5 . 22937671 . free . 1988FEBSL.231..164W .
3. Web site: Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2.
4. Mears HV, Sweeney TR . Better together: the role of IFIT protein-protein interactions in the antiviral response . The Journal of General Virology . 99 . 11 . 1463–1477 . November 2018 . 30234477 . 10.1099/jgv.0.001149 . free .
5. Zhou X, Michal JJ, Zhang L, Ding B, Lunney JK, Liu B, Jiang Z . Interferon induced IFIT family genes in host antiviral defense . International Journal of Biological Sciences . 9 . 2 . 200–8 . 2013 . 23459883 . 3584916 . 10.7150/ijbs.5613 .
6. Lang R, Li H, Luo X, Liu C, Zhang Y, Guo S, Xu J, Bao C, Dong W, Yu Y . Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases . Frontiers in Immunology . 13 . 1008072 . 2022 . 36325336 . 10.3389/fimmu.2022.1008072 . free . 9618809 .
7. Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC . IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma . Mol. Cancer Res. . 6 . 9 . 1431–9 . 2008 . 18819931 . 10.1158/1541-7786.MCR-08-0141 . free .
8. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F . Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. . J Cell Physiol . 230. 4 . 802–812 . April 2015 . 25205602 . 10.1002/jcp.24808. 11392/2066612 . 24986454 . free .
9. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F . Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. . J Cell Physiol . 230. 4 . 802–812 . April 2015 . 25205602 . 10.1002/jcp.24808. 11392/2066612 . 24986454 . free .