Isotryptamine Explained

Isotryptamine, also known as 2-(1-indolyl)ethylamine, is a chemical compound and positional isomer of tryptamine (2-(3-indolyl)ethylamine).[1] A variety of isotryptamine derivatives, or substituted isotryptamines, have been studied and described.[2] [3] [4] [5] [6] [7]

See also

Notes and References

  1. Web site: 2-(1H-indol-1-yl)ethanamine . PubChem . 14 November 2024.
  2. Glennon RA, Jacyno JM, Young R, McKenney JD, Nelson D . Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines . J Med Chem . 27 . 1 . 41–45 . January 1984 . 6581313 . 10.1021/jm00367a008 .
  3. Dunlap LE, Azinfar A, Ly C, Cameron LP, Viswanathan J, Tombari RJ, Myers-Turnbull D, Taylor JC, Grodzki AC, Lein PJ, Kokel D, Olson DE . Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies . J Med Chem . 63 . 3 . 1142–1155 . February 2020 . 31977208 . 10.1021/acs.jmedchem.9b01404 . 7075704 .
  4. Duan W, Cao D, Wang S, Cheng J . Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants . Chem Rev . 124 . 1 . 124–163 . January 2024 . 38033123 . 10.1021/acs.chemrev.3c00375 .
  5. Atiq MA, Baker MR, Voort JL, Vargas MV, Choi DS . Disentangling the acute subjective effects of classic psychedelics from their enduring therapeutic properties . Psychopharmacology (Berl) . May 2024 . 38743110 . 10.1007/s00213-024-06599-5 . free . 12226698 .
  6. Rasmussen K, Chytil M, Agrawal R, Leach P, Gillie D, Mungenast A, Vancutsem P, Engel S, Meyer R, Koenig A, Rus M . 14. Preclinical Pharmacology of DLX-001, a Novel Non-Hallucinogenic Neuroplastogen With the Potential for Treating Neuropsychiatric Diseases . Biological Psychiatry . Elsevier BV . 95 . 10 . 2024 . 0006-3223 . 10.1016/j.biopsych.2024.02.192 . S80.
  7. Rasmussen K, Engel S, Chytil M, Koenig A, Meyer R, Rus M, Olson D, Salinas E . ACNP 62nd Annual Meeting: Poster Abstracts P251 - P500: P361. Preclinical Pharmacology of DLX-001, a Novel Non-Hallucinogenic Neuroplastogen With the Potential for Treating Neuropsychiatric Diseases . Neuropsychopharmacology . 48 . Suppl 1 . 211–354 (274–275) . December 2023 . 38040810 . 10729596 . 10.1038/s41386-023-01756-4 .

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