MDAT explained

Image Class:skin-invert-image
Width:250px
Class:Serotonin releasing agent
Entactogen
Atc Prefix:None
Legal Status:Uncontrolled
Index2 Label:hydrochloride
Cas Number:101625-35-8
Cas Number2:3446-21-8
Unii:28IR5LC41Q
Unii2:BOX4U52EET
Pubchem:36483
Chemspiderid:33531
Synonyms:6,7-MDAT; 6,7-Methylenedioxy-2-aminotetralin
Iupac Name:5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxol-6-amine
C:11
H:13
N:1
O:2
Smiles:C3Cc1cc2OCOc2cc1CC3N

MDAT, also known as 6,7-methylenedioxy-2-aminotetralin, is a drug of the 2-aminotetralin family developed in the 1990s by a team at Purdue University led by David E. Nichols.[1] It appears to act as a serotonin releasing agent based on rodent drug discrimination assays comparing it to MDMA, in which it fully substitutes for, and additionally lacks any kind of serotonergic neurotoxicity.[1] Hence, MDAT is considered likely to be a non-neurotoxic, putative entactogen in humans.

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Notes and References

  1. Nichols DE, Brewster WK, Johnson MP, Oberlender R, Riggs RM . Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA) . Journal of Medicinal Chemistry . 33 . 2 . 703–10 . February 1990 . 1967651 . 10.1021/jm00164a037.