Propylnitazene Explained

Propylnitazene (PPZ) is a benzimidazole derivative which has opioid effects and has been sold as a designer drug. It is less potent than many of the "nitazene" group of opioids which have been sold on the illicit market, but is nevertheless a potent opioid drug with around fifty times the potency of morphine.^{[1] [2] [3] [4]}

See also

• Menitazene
• Protonitazene
• List of benzimidazole opioids

Notes and References

1. Hunger A, Kebrle J, Rossi A, Hoffmann K . Benzimidazole-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen. . Helvetica Chimica Acta . 43 . 4 . 1032–1046 . 1960 . 10.1002/hlca.19600430412 .
2. Kozell LB, Eshleman AJ, Wolfrum KM, Swanson TL, Bloom SH, Benware S, Schmachtenberg JL, Schutzer KA, Schutzer WE, Janowsky A, Abbas AI . Pharmacologic Characterization of Substituted Nitazenes at μ, κ, and Δ Opioid Receptors Suggests High Potential for Toxicity . The Journal of Pharmacology and Experimental Therapeutics . 389 . 2 . 219–228 . April 2024 . 38453524 . 11026150 . 10.1124/jpet.123.002052 .
3. Phelps C, Hardwick EK, Couch AN, Davidson JT . Development and validation of a combined selected ion monitoring-scan GC-EI-MS method for nitazene analogs . Journal of Forensic Sciences . May 2025 . 1556-4029.70084 . 40390160 . 10.1111/1556-4029.70084 .
4. Stove CP, Vandeputte MM, Glatfelter GC, Walther D, Layle NK, Germaine DM, Ujváry I, Iula DM, Baumann MH . Nitazenes of the Past, Present, and Future: Insights from In Vitro µ-opioid Receptor Assays and In Vivo Behavioral Studies in Mice . 162711 . The Journal of Pharmacology and Experimental Therapeutics . March 2025 . 392 . 3 . 10.1016/j.jpet.2024.101052 .