RNF167 explained

Ring finger protein 167 is a protein that in humans is encoded by the RNF167 gene.^[1]

Function

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation.^[2]

Further reading

• Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW . Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission . Proc. Natl. Acad. Sci. U.S.A. . 109 . 47 . 19426–31 . November 2012 . 23129617 . 3511152 . 10.1073/pnas.1217477109 . 2012PNAS..10919426L . free .
• Yamazaki Y, Schönherr C, Varshney GK, Dogru M, Hallberg B, Palmer RH . Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation . EMBO J. . 32 . 4 . 524–37 . February 2013 . 23353890 . 3579141 . 10.1038/emboj.2013.1 .
• van Dijk JR, Yamazaki Y, Palmer RH . Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization . Biochem. J. . 459 . 1 . 27–36 . April 2014 . 24387786 . 10.1042/BJ20131067 .

Notes and References

1. Web site: Entrez Gene: Ring finger protein 167. 2018-09-10.
2. Yamada . H. Y. . Gorbsky . G. J. . March 2006 . Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 . Oncogene . 25 . 9 . 1330–1339 . 10.1038/sj.onc.1209167 . 1476-5594. 2713668 .