WDR26 explained
WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.[1]
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
Clinical significance
Pathogenic variants of the gene cause Skraban–Deardorff syndrome.[2]
Further reading
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
- Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H . CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation . Nature Cell Biology . 8 . 11 . 1277–1283 . Nov 2006 . 17041588 . 10.1038/ncb1490 . 22180568 .
- Zhu Y, Wang Y, Xia C, Li D, Li Y, Zeng W, Yuan W, Liu H, Zhu C, Wu X, Liu M . WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway . Journal of Cellular Biochemistry . 93 . 3 . 579–587 . Oct 2004 . 15378603 . 10.1002/jcb.20175 . 86601953 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
Notes and References
- Web site: Entrez Gene: WDR26 WD repeat domain 26 .
- Gross A, Müller J, Chrustowicz J, Strasser A, Gottemukkala K, Sherpa D, Schulman B, Murray P, Alpi A . Skraban–Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly . FEBS Letters . Cambridge, England . 598 . 9 . 978–994 . 2024-04-04 . 38575527 . 7616460 . 10.1002/1873-3468.14866 . free . . 1873-3468 .
