Aglepristone Explained

Aglepristone (brand name Alizin; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone.^{[1] [2] [3]} Aglepristone, similarly to mifepristone, also possesses some antiglucocorticoid activity.^{[4] [5]} Aglepristone is used as an abortifacent, to induce parturition, and as a treatment for mammary hyperplasia and pyometra. It is only used in cats and dogs.^[6]

See also

• Lilopristone
• Onapristone
• Telapristone
• Toripristone

Notes and References

1. Book: Kaufman LK, Baldwin CJ . Pregnancy Loss in the Bitch and Queen . Bonagura JD, Twedt DC . Kirk's Current Veterinary Therapy XV. https://books.google.com/books?id=KlJKAgAAQBAJ&pg=PT3009. 1 December 2013. Elsevier Health Sciences. 978-0-323-22762-9. 3009–.
2. Book: Squires EJ . Endocrine manipulation of reproduction. . Applied Animal Endocrinology. https://books.google.com/books?id=Q-rP6Fc9-N4C&pg=PA207. 2010. CABI. 978-1-84593-755-3. 207–.
3. Book: Aglepristone . Papich MC . Saunders Handbook of Veterinary Drugs: Small and Large Animal. https://books.google.com/books?id=PeJTVfaAiYAC&pg=PT120. 3 November 2010. Elsevier Health Sciences. 978-1-4377-0192-0. 120–.
4. Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, Cabrera F, Gracia A . 6 . Induction of parturition with aglepristone in the Majorera goat . Reproduction in Domestic Animals = Zuchthygiene . 46 . 5 . 882–888 . October 2011 . 21320179 . 10.1111/j.1439-0531.2011.01759.x .
5. Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC . Hormonal changes in spontaneous and aglépristone-induced parturition in dogs . Theriogenology . 69 . 4 . 399–407 . March 2008 . 18054071 . 10.1016/j.theriogenology.2007.10.008 .
6. Book: Saunders Handbook of Veterinary Drugs. Mark. Papich. Elsevier. 2016. 978-0-323-24485-5. 4th.