Dieckol Explained

Dieckol is a phlorotannin that can be found in arame (Eisenia bicyclis),^{[1] [2]} in Ecklonia cava^[3] or in Ecklonia stolonifera.^{[4] [5]}

This compound shows antithrombotic and profibrinolytic activities.^[2] It has also an effect on hair growth.^[6]

Dieckol is a GSK-3β inhibitor.^{[7] [8]}

See also

• Procyanidin B3, a proanthocyanidin dimer with the same hair growth-promoting effect

Notes and References

1. 20462757. 2010. Jung. HA. Oh. SH. Choi. JS. Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. 20. 11. 3211–5. 10.1016/j.bmcl.2010.04.093. Bioorganic & Medicinal Chemistry Letters.
2. 10.1002/jcb.24163. Antithrombotic and profibrinolytic activities of eckol and dieckol. 2012. Kim. Tae Hoon. Ku. Sae-Kwang. Bae. Jong-Sup. Journal of Cellular Biochemistry. 113. 9. 2877–83. 22511271. 2151927.
3. 10.1016/j.fct.2010.06.032. Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. 2010. Lee. Seung-Hong. Park. Mi-Hwa. Heo. Soo-Jin. Kang. Sung-Myung. Ko. Seok-Chun. Han. Ji-Sook. Jeon. You-Jin. Food and Chemical Toxicology. 48. 10. 2633–7. 20600532.
4. 20422362. 2010. Goo. HR. Choi. JS. Na. DH. Quantitative determination of major phlorotannins in Ecklonia stolonifera. 33. 4. 539–44. 10.1007/s12272-010-0407-y. Archives of Pharmacal Research. 26981463.
5. 16880634. 2006. Joe. MJ. Kim. SN. Choi. HY. Shin. WS. Park. GM. Kang. DW. Kim. YK. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. 29. 8. 1735–9. Biological & Pharmaceutical Bulletin. 10.1248/bpb.29.1735. free.
6. 10.3390/ijms13056407. 22754373. Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth. 2012. Kang. Jung-Il. Kim. Sang-Cheol. Kim. Min-Kyoung. Boo. Hye-Jin. Jeon. You-Jin. Koh. Young-Sang. Yoo. Eun-Sook. Kang. Sung-Myung. Kang. Hee-Kyoung. International Journal of Molecular Sciences. 13. 12. 6407–23. 3382810 . free .
7. Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell . Mar Drugs . 15 March 2021 . 19 . 3 . 152 . 10.3390/md19030152 . 8001366. 33804171. Yoon JH, Lee N, Youn K, Jo MR, Kim HR, Lee DS, Ho CT, Jun M . free .
8. Natural compounds from herbs and nutraceuticals as glycogen synthase kinase-3β inhibitors in Alzheimer's disease treatment . CNS Neuroscience & Therapeutics . 11 August 2024 . 30 . 8 . 10.1111/cns.14885 . 11317746. 39129397. Zheng Zhao, Ye Yuan, Shuang Li, Xiaofeng Wang, Xue Yang . e14885 .