GAMMA (drug)

GAMMA
Clinical data
Other names	γ; homo-MDPEA; 3,4-Methylenedioxyphenyl-propylamine; 1-Amino-3-(3,4-methylenedioxyphenyl)propane
Routes of; administration	Oral
Drug class	Psychoactive drug
ATC code	None;
Pharmacokinetic data
Duration of action	4 hours
Identifiers
	IUPAC name 3-(1,3-benzodioxol-5-yl)propan-1-amine;
CAS Number	6301-13-9; 78498-59-6;
PubChem CID	413015;
ChemSpider	365714;
CompTox Dashboard (EPA)	DTXSID00328675;
Chemical and physical data
Formula	C10H13NO2
Molar mass	179.219 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1OC2=C(O1)C=C(C=C2)CCCN;
	InChI InChI=1S/C10H13NO2/c11-5-1-2-8-3-4-9-10(6-8)13-7-12-9/h3-4,6H,1-2,5,7,11H2; Key:CLJLCLGOWKOKJF-UHFFFAOYSA-N;

GAMMA, also known as homo-MDPEA or as 3,4-methylenedioxyphenylpropylamine, is a psychoactive drug belonging to the 3-phenylpropylamine family (compounds related to phenethylamines with a three-carbon chain) and a compound related to methylenedioxyphenethylamines.^[1]^[2]^[3]

Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists GAMMA's dose as 200 mg orally and its duration as 4 hours.^[1] The effects of GAMMA have been reported to include "some physical ill-at-ease, possible time distortion, and a feeling of being keenly aware of one's surroundings".^[1]

Analogues of GAMMA include homo-MDA and homo-MDMA, among others.^[1]

GAMMA was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III by 1982.^[3] Subsequently it was described further by Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) in 1991.^[1]

1 2 3 4 5 6 7 Shulgin AT, Shulgin A. "entry 100: GAMMA". PiHKAL: A Chemical Love Story. Book II. Isomer Design [Internet]. Retrieved 2026-09-09.
↑ Shulgin A. The Shulgin Index (The 23 homo-phenylethylamines compounds in table 10, page 358).
1 2 Shulgin AT, Jacob P (March 1982). "1-(3,4-methylenedioxyphenyl)-3-aminobutane: a potential toxicological problem". J Toxicol Clin Toxicol. 19 (1): 109–110. doi:10.3109/15563658208990371. PMID 7154137.