Propylcathinone Explained
| Image Class: | skin-invert-image |
| Class: | Stimulant
- Monoamine releasing agent; Monoamine reuptake inhibitor
|
| Cas Number: | 52597-14-5 |
| Pubchem: | 45049 |
| Chemspiderid: | 40983 |
| Unii: | 5AJ9EZ7U7S |
| Synonyms: | PC; PrC; 2-(Propylamino)propanophenone; α-Propylaminopropiophenone; PAP; N-Propylcathinone; β-Keto-N-propylamphetamine; N-Pr-CAT; PAL-359; PAL359 |
| Iupac Name: | 1-phenyl-2-(propylamino)propan-1-one |
| C: | 12 |
| H: | 17 |
| N: | 1 |
| O: | 1 |
| Smiles: | CCCNC(C)C(=O)C1=CC=CC=C1 |
| Stdinchi: | 1S/C12H17NO/c1-3-9-13-10(2)12(14)11-7-5-4-6-8-11/h4-8,10,13H,3,9H2,1-2H3 |
| Stdinchikey: | GXPFWFAQFTVCDU-UHFFFAOYSA-N |
Propylcathinone (code name PAL-359), or N-propylcathinone, is a stimulant and designer drug of the amphetamine and cathinone families.[1] It is known to be inactive as a dopamine reuptake inhibitor and releasing agent.[2] Nonetheless, the drug substitutes for dextroamphetamine in animal drug discrimination tests. The related agent propylamphetamine is known to be partially metabolized into amphetamine and this is thought to be involved in its effects.[3] [4] Propylcathinone was first encountered as a novel designer drug in Europe by 2015.[5] [6] [7]
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Notes and References
- Dal Cason TA, Young R, Glennon RA . Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs . Pharmacology, Biochemistry, and Behavior . 58 . 4 . 1109–1116 . December 1997 . 9408221 . 10.1016/s0091-3057(97)00323-7 .
- Reith ME, Blough BE, Hong WC, Jones KT, Schmitt KC, Baumann MH, Partilla JS, Rothman RB, Katz JL . Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter . Drug and Alcohol Dependence . 147 . 1–19 . February 2015 . 25548026 . 4297708 . 10.1016/j.drugalcdep.2014.12.005 .
- Beckett AH, Shenoy EV . The effect of N-alkyl chain length of stereochemistry on the absorption, metabolism and during excretion of N-alkylamphetamines in man . The Journal of Pharmacy and Pharmacology . 25 . 10 . 793–799 . October 1973 . 4151673 . 10.1111/j.2042-7158.1973.tb09943.x .
- Coutts RT, Dawson GW, Beckett AH . In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates . The Journal of Pharmacy and Pharmacology . 28 . 11 . 815–821 . November 1976 . 11289 . 10.1111/j.2042-7158.1976.tb04063.x .
- Web site: 2015 Annual Reports on the implementation of Council Decision 2005/387/JHA . Europol . 23 October 2018 . 12 March 2025.
- Błażewicz A, Bednarek E, Popławska M, Olech N, Sitkowski J, Kozerski L . Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone . Forensic Toxicology . 37 . 2 . 2019 . 1860-8965 . 10.1007/s11419-018-00463-w . free . 288–307 . 12 March 2025.
- Pulver B, Fischmann S, Gallegos A, Christie R . EMCDDA framework and practical guidance for naming cathinones . Drug Testing and Analysis . 16 . 12 . 1409–1435 . December 2024 . 38389255 . 11635063 . 10.1002/dta.3662 .
